diff --git a/CMakeLists.txt b/CMakeLists.txt
index af372be63..6487ac420 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -319,11 +319,15 @@ if(BUILD_TESTING)
     set(TESTOPTS -l ${EXTRATESTOPTS})
     set(TESTPROG ${CMAKE_BINARY_DIR}/${PYTHONHOME}/test/regrtest.py)
     set(TESTPYTHONOPTS )
+    set(TESTPYTHONWRAPPER )
+    if(APPLE AND BUILD_SHARED)
+        set(TESTPYTHONWRAPPER env DYLD_LIBRARY_PATH=${CMAKE_BINARY_DIR}/${LIBPYTHON_LIBDIR})
+    endif()
     set(TESTPYTHON $<TARGET_FILE:python> -Wd -3 -E -tt ${TESTPYTHONOPTS})
 
     include(cmake/UnitTests.cmake)
     foreach(unittest ${unittests})
-      add_test(NAME ${unittest} COMMAND ${TESTPYTHON} ${TESTPROG} ${TESTOPTS} ${unittest})
+      add_test(NAME ${unittest} COMMAND ${TESTPYTHONWRAPPER} ${TESTPYTHON} ${TESTPROG} ${TESTOPTS} ${unittest})
     endforeach(unittest)
 endif(BUILD_TESTING)
 
diff --git a/cmake/python/CMakeLists.txt b/cmake/python/CMakeLists.txt
index acd36d2e5..0638704e1 100644
--- a/cmake/python/CMakeLists.txt
+++ b/cmake/python/CMakeLists.txt
@@ -24,9 +24,13 @@ install(TARGETS python EXPORT PythonTargets RUNTIME DESTINATION ${BIN_INSTALL_DI
 
 if(UNIX AND PY_VERSION VERSION_GREATER "2.7.4")
     # Setup landmark allowing to run the interpreter from a build tree. See 'getpath.c' for details.
+    set(PYTHON_WRAPPER_COMMAND )
+    if(APPLE AND BUILD_SHARED)
+        set(PYTHON_WRAPPER_COMMAND env DYLD_LIBRARY_PATH="${CMAKE_BINARY_DIR}/${LIBPYTHON_LIBDIR}")
+    endif()
     add_custom_command(
         OUTPUT ${BIN_BUILD_DIR}/pybuilddir.txt ${EXTENSION_BUILD_DIR}/_sysconfigdata.py
-        COMMAND $<TARGET_FILE:python> -E -S -m sysconfig --generate-posix-vars
+        COMMAND ${PYTHON_WRAPPER_COMMAND} $<TARGET_FILE:python> -E -S -m sysconfig --generate-posix-vars
         COMMAND ${CMAKE_COMMAND}
           -DBIN_BUILD_DIR:PATH=${BIN_BUILD_DIR}
           -DPYTHON_BINARY_DIR:PATH=${CMAKE_BINARY_DIR}