import matplotlib.pyplot as plt
from matplotlib.transforms import Affine2D
import numpy as np

img = np.random.random((100, 20, 3))

tr_rotate = Affine2D().rotate_deg_around(0 / 2, 0 / 2, 45)
tr_translate = Affine2D().translate(250, 250)

fig, ax = plt.subplots()

ax.imshow(
    img,
    transform=tr_rotate + ax.transData,
    clip_on=False,
)

ax.imshow(
    img,
    transform=tr_translate + ax.transData,
    clip_on=False,
)

ax.set_xlim(-250, 500)
ax.set_ylim(-250, 500)

fig.savefig("MWE.png")