diff --git a/packages/google-cloud-bigquery/google/cloud/bigquery/client.py b/packages/google-cloud-bigquery/google/cloud/bigquery/client.py
index ce8768b68b30..7494ffb214b6 100644
--- a/packages/google-cloud-bigquery/google/cloud/bigquery/client.py
+++ b/packages/google-cloud-bigquery/google/cloud/bigquery/client.py
@@ -163,6 +163,16 @@
 # https://github.com/googleapis/python-bigquery/issues/438
 _MIN_GET_QUERY_RESULTS_TIMEOUT = 120
 
+_LOAD_TABLE_FROM_DATAFRAME_DEPRECATED = (
+    "Loading DataFrames via google-cloud-bigquery is deprecated. "
+    "For direct, optimized loading, please call 'pandas_gbq.to_gbq()' directly."
+)
+
+_INSERT_ROWS_FROM_DATAFRAME_DEPRECATED = (
+    "Inserting rows from DataFrames via google-cloud-bigquery is deprecated. "
+    "For direct, optimized access, please call 'pandas_gbq.to_gbq()' directly."
+)
+
 TIMEOUT_HEADER = "X-Server-Timeout"
 
 
@@ -2830,6 +2840,12 @@ def load_table_from_dataframe(
                 If ``job_config`` is not an instance of
                 :class:`~google.cloud.bigquery.job.LoadJobConfig` class.
         """
+        warnings.warn(
+            _LOAD_TABLE_FROM_DATAFRAME_DEPRECATED,
+            PendingDeprecationWarning,
+            stacklevel=2,
+        )
+
         job_id = _make_job_id(job_id, job_id_prefix)
 
         if job_config is not None:
@@ -3900,6 +3916,12 @@ def insert_rows_from_dataframe(
         Raises:
             ValueError: if table's schema is not set
         """
+        warnings.warn(
+            _INSERT_ROWS_FROM_DATAFRAME_DEPRECATED,
+            PendingDeprecationWarning,
+            stacklevel=2,
+        )
+
         insert_results = []
 
         chunk_count = int(math.ceil(len(dataframe) / chunk_size))
diff --git a/packages/google-cloud-bigquery/tests/unit/test_client.py b/packages/google-cloud-bigquery/tests/unit/test_client.py
index 9df85b7372e5..d9c7fbbfbe5a 100644
--- a/packages/google-cloud-bigquery/tests/unit/test_client.py
+++ b/packages/google-cloud-bigquery/tests/unit/test_client.py
@@ -6579,6 +6579,26 @@ def test_insert_rows_from_dataframe_w_explicit_none_insert_ids(self):
             timeout=DEFAULT_TIMEOUT,
         )
 
+    def test_insert_rows_from_dataframe_emits_pending_deprecation_warning(self):
+        pandas = pytest.importorskip("pandas")
+        from google.cloud.bigquery.schema import SchemaField
+        from google.cloud.bigquery.table import Table
+
+        creds = _make_credentials()
+        http = object()
+        client = self._make_one(project=self.PROJECT, credentials=creds, _http=http)
+        client._connection = make_connection({}, {})
+
+        schema = [SchemaField("name", "STRING", mode="REQUIRED")]
+        table = Table(self.TABLE_REF, schema=schema)
+        dataframe = pandas.DataFrame([{"name": "Alice"}])
+
+        with pytest.warns(
+            PendingDeprecationWarning,
+            match="Inserting rows from DataFrames via google-cloud-bigquery is deprecated",
+        ):
+            client.insert_rows_from_dataframe(table, dataframe)
+
     def test_insert_rows_json_default_behavior(self):
         from google.cloud.bigquery.dataset import DatasetReference
         from google.cloud.bigquery.schema import SchemaField
@@ -6841,10 +6861,10 @@ def test_insert_rows_w_wrong_arg(self):
             client.insert_rows_json(table, ROW)
 
     def test_insert_rows_json_w_ssl_error(self):
+        import requests.exceptions
         from google.cloud.bigquery.dataset import DatasetReference
         from google.cloud.bigquery.schema import SchemaField
         from google.cloud.bigquery.table import Table
-        import requests.exceptions
 
         PROJECT = "PROJECT"
         DS_ID = "DS_ID"
@@ -9390,6 +9410,25 @@ def test_load_table_from_dataframe_w_higher_scale_decimal128_datatype(self):
             SchemaField("x", "BIGNUMERIC", "NULLABLE", None),
         )
 
+    def test_load_table_from_dataframe_emits_pending_deprecation_warning(self):
+        pandas = pytest.importorskip("pandas")
+        pytest.importorskip("pyarrow")
+
+        client = self._make_client()
+        dataframe = pandas.DataFrame({"x": [1, 2, 3]})
+
+        load_patch = mock.patch(
+            "google.cloud.bigquery.client.Client.load_table_from_file", autospec=True
+        )
+        get_table_patch = mock.patch(
+            "google.cloud.bigquery.client.Client.get_table", autospec=True
+        )
+        with load_patch, get_table_patch, pytest.warns(
+            PendingDeprecationWarning,
+            match="Loading DataFrames via google-cloud-bigquery is deprecated",
+        ):
+            client.load_table_from_dataframe(dataframe, self.TABLE_REF)
+
     # With autodetect specified, we pass the value as is. For more info, see
     # https://github.com/googleapis/python-bigquery/issues/1228#issuecomment-1910946297
     def test_load_table_from_json_basic_use(self):