diff --git a/.github/workflows/unittest.yml b/.github/workflows/unittest.yml
index 7b1809e1c5f0..f925868d8248 100644
--- a/.github/workflows/unittest.yml
+++ b/.github/workflows/unittest.yml
@@ -30,12 +30,18 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: ${{ matrix.python }}
+    - name: Setup uv
+      uses: astral-sh/setup-uv@v5
+      with:
+        enable-cache: true
     - name: Install nox
       run: |
-        python -m pip install --upgrade setuptools pip wheel
-        python -m pip install nox
+        uv pip install --system "nox[uv]"
     - name: Run unit tests
       env:
+        NOX_DEFAULT_VENV_BACKEND: uv
+        UV_VENV_SEED: 1 
+        UV_COMPILE_BYTECODE: 1
         COVERAGE_FILE: .coverage-${{ matrix.python }}
         BUILD_TYPE: presubmit
         TARGET_BRANCH: ${{ github.base_ref || github.event.merge_group.base_ref }}
@@ -68,12 +74,18 @@ jobs:
       with:
         python-version: ${{ matrix.python }}
         allow-prereleases: true
+    - name: Setup uv
+      uses: astral-sh/setup-uv@v5
+      with:
+        enable-cache: true
     - name: Install nox
       run: |
-        python -m pip install --upgrade setuptools pip wheel
-        python -m pip install nox
+        uv pip install --system "nox[uv]"
     - name: Run ${{ matrix.option }} tests
       env:
+        NOX_DEFAULT_VENV_BACKEND: uv
+        UV_VENV_SEED: 1 
+        UV_COMPILE_BYTECODE: 1
         BUILD_TYPE: presubmit
         TARGET_BRANCH: ${{ github.base_ref || github.event.merge_group.base_ref }}
         TEST_TYPE: ${{ matrix.option }}
@@ -100,12 +112,18 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: ${{ matrix.python }}
+    - name: Setup uv
+      uses: astral-sh/setup-uv@v5
+      with:
+        enable-cache: true
     - name: Install nox
       run: |
-        python -m pip install --upgrade setuptools pip wheel
-        python -m pip install nox
+        uv pip install --system "nox[uv]"
     - name: Run ${{ matrix.option }} tests
       env:
+        NOX_DEFAULT_VENV_BACKEND: uv
+        UV_VENV_SEED: 1 
+        UV_COMPILE_BYTECODE: 1
         BUILD_TYPE: presubmit
         TARGET_BRANCH: ${{ github.base_ref || github.event.merge_group.base_ref }}
         TEST_TYPE: ${{ matrix.option }}
@@ -133,11 +151,15 @@ jobs:
     - name: Set number of files changes in packages directory
       id: packages
       run: echo "::set-output name=num_files_changed::$(git diff HEAD~1 -- packages | wc -l)"
+    - name: Setup uv
+      if: steps.packages.outputs.num_files_changed > 0 || steps.packages.num_files_changed > 0
+      uses: astral-sh/setup-uv@v5
+      with:
+        enable-cache: true
     - name: Install coverage
-      if: steps.packages.num_files_changed > 0
+      if: steps.packages.outputs.num_files_changed > 0 || steps.packages.num_files_changed > 0
       run: |
-        python -m pip install --upgrade setuptools pip wheel
-        python -m pip install coverage
+        uv pip install --system coverage
     - name: Download coverage results
       if: ${{ steps.date.packages.num_files_changed > 0 }}
       uses: actions/download-artifact@v4