diff --git a/src/LuaTransformer.ts b/src/LuaTransformer.ts
index e060b6ad3..3c9fb2c89 100644
--- a/src/LuaTransformer.ts
+++ b/src/LuaTransformer.ts
@@ -2628,10 +2628,6 @@ export class LuaTransformer {
     }
 
     public transformForInStatement(statement: ts.ForInStatement): StatementVisitResult {
-        // Get variable identifier
-        const variable = (statement.initializer as ts.VariableDeclarationList).declarations[0];
-        const identifier = variable.name as ts.Identifier;
-
         // Transpile expression
         const pairsIdentifier = tstl.createIdentifier("pairs");
         const expression = this.transformExpression(statement.expression);
@@ -2643,7 +2639,30 @@ export class LuaTransformer {
 
         const body = tstl.createBlock(this.transformLoopBody(statement));
 
-        return tstl.createForInStatement(body, [this.transformIdentifier(identifier)], [pairsCall], statement);
+        // Transform iteration variable
+        // TODO: After the transformation pipeline refactor we should look at refactoring this together with the
+        // for-of initializer transformation.
+        let iterationVariable: tstl.Identifier;
+        if (
+            ts.isVariableDeclarationList(statement.initializer) &&
+            ts.isIdentifier(statement.initializer.declarations[0].name)
+        ) {
+            iterationVariable = this.transformIdentifier(statement.initializer.declarations[0].name);
+        } else if (ts.isIdentifier(statement.initializer)) {
+            // Iteration variable becomes ____key
+            iterationVariable = tstl.createIdentifier("____key");
+            // Push variable = ____key to the start of the loop body to match TS scoping
+            const initializer = tstl.createAssignmentStatement(
+                this.transformIdentifier(statement.initializer),
+                iterationVariable
+            );
+            body.statements.unshift(initializer);
+        } else {
+            // This should never occur
+            throw TSTLErrors.UnsupportedForInVariable(statement.initializer);
+        }
+
+        return tstl.createForInStatement(body, [iterationVariable], [pairsCall], statement);
     }
 
     public transformSwitchStatement(statement: ts.SwitchStatement): StatementVisitResult {
diff --git a/src/TSTLErrors.ts b/src/TSTLErrors.ts
index 7318b9cd0..89867e01d 100644
--- a/src/TSTLErrors.ts
+++ b/src/TSTLErrors.ts
@@ -77,6 +77,9 @@ export const NonFlattenableDestructure = (node: ts.Node) =>
 export const UndefinedFunctionDefinition = (functionSymbolId: number) =>
     new Error(`Function definition for function symbol ${functionSymbolId} is undefined.`);
 
+export const UnsupportedForInVariable = (initializer: ts.Node) =>
+    new TranspileError(`Unsuppored for-in variable kind.`, initializer);
+
 export const UndefinedScope = () => new Error("Expected to pop a scope, but found undefined.");
 
 export const UndefinedTypeNode = (node: ts.Node) => new TranspileError("Failed to resolve required type node.", node);
diff --git a/test/unit/loops.spec.ts b/test/unit/loops.spec.ts
index 34e92998a..4d50dca20 100644
--- a/test/unit/loops.spec.ts
+++ b/test/unit/loops.spec.ts
@@ -630,3 +630,27 @@ test("do...while double-negation", () => {
     expect(util.transpileString(code)).not.toMatch("not");
     expect(util.transpileAndExecute(code)).toBe(2);
 });
+
+test("for...in with pre-defined variable", () => {
+    util.testFunction`
+        const obj = { x: "y", foo: "bar" };
+
+        let x = "";
+        let result = [];
+        for (x in obj) {
+            result.push(x);
+        }
+        return result;
+    `.expectToMatchJsResult();
+});
+
+test("for...in with pre-defined variable keeps last value", () => {
+    util.testFunction`
+        const obj = { x: "y", foo: "bar" };
+
+        let x = "";
+        for (x in obj) {
+        }
+        return x;
+    `.expectToMatchJsResult();
+});